Williams, 41, has won seven major titles, including victories at Flushing Meadows in 2000 and 2001.
But together with her current WTA ranking of No.
112, she has fallen outside the highest 104 who receive direct entry into the women’s main draw.
Williams hasn’t missed the US Open since 2006, when she was sidelined by a left wrist injury.
She reached her last major semifinal at the tournament in 2017.